Ph. D, Professor, Doctoral Supervisor

Chief scientist of innovation group

Education background

Bachelor of Science, Pharmaceutics, JiLin University, 2005.9-2009.7

Ph.D, Biochemistry and Molecular Biology, Tsinghua University, 2009.9-2014.7

Research interest

1. Biomass enzymatic hydrolysis and conversion：Screen and identify new plant cell wall degrading microbial consortia and enzymes (xylanase, pectinase, etc.), clarify their regulation mechanism via enzyme kinetic and structural studies. Identify food functional ingredients bioconversion intestinal microbiota and enzymes, clarify the underlying catalytic mechanisms.
2. Biosynthesis of functional ingredients and food additives: Engineering enzymes to produce valuable building blocks and integrating into different microorganisms for the synthesis of food bioactive components (vanillin, curcumin , etc.).
3. Functional fortified food development: Based on the domestically identified and studied enzymes and microorganisms (probiotics, etc.) to develop the bio-conversed functional fortified food.

Selected publications

1. Yao XY*, Lv YM*, Yu HL, Cao H, Wang LY, Wen BT, Gu TY, Wang FZ*, Sun LC*, Xin FJ*. Site-directed mutagenesis of coenzyme-independent carotenoid oxygenase CSO2 to enhance the enzymatic synthesis of vanillin. Applied Microbiology and Technology. 2020. (IF 3.67)
2. Chen M*, Fan B*, Liu SJ, Khandaker MD Sharif Uddin Imam, Xie YY, Wen BT*, Xin FJ*. The in vitro effect of fibers with different degrees of polymerization on human gut bacteria. Frontiers in Microbiology. 2020. (IF 4.259)
3. Khandaker MD Sharif Uddin Imam*, Xie YY*, Liu YS, Wang FZ*, Xin FJ*. Cytotoxicity of Cichorium intybus L. metabolites. Oncology Reports. 2019. (IF 3.041)
4. Cao H*, Sun LC*, Huang Ying, Liu X, Yang Dong, Liu TF, Jia XJ, Wen BT, Gu TY, Wang FZ*, Xin FJ*. Structural insight into the dual-substrates recognizing and catalytic mechanism ofacetyl ester-xyloside bifunctional hydrolase from Caldicellulosiruptor lactoaceticus. ACS Catalysis. 2019. (IF 12.221)
5. Jia N*, Liu JQ, Sun YF, Tan PH, Sun YF, Lv YM, Liu JM, Sun J, Huang YT, Lu J, Jin N, Li MM, Khandaker Md Sharif Uddin Imam, Xin FJ*, Fan Bei*. Citrus sinensis MYB transcription factor CsMYB85 induce fruit juice sac lignification through interaction with other CsMYB transcription factors. Frontiers in Plant Science. 2019. ( IF 3.677 )
6. Xie YY*, Li SY*, Sun L*, Liu SJ, Wang FZ, Wen BT, Sun LC, Fang XD, Chai YS, Cao H, Jia N, Gu TY, Lou XM*, Xin FJ*. Fungal immunomodulatory protein from Nectria haematococca suppresses growth of human lung adenocarcinoma by inhibiting the PI3K/Akt pathway. International Journal of Molecular Sciences. 2018. ( IF 4.183 )
7. Jia N*, Liu JQ, Sun YF, Tan PH, Cao H, Xie YY, Wen BT, Gu TY, Liu JM, Li MM, Huang YT, Lu J, Jin N, Sun LC, Xin FJ*, Fan Bei*. Citrus sinensis MYB transcription factors CsMYB330 and CsMYB308 regulate fruit juice sac lignification through finetuning expression of the Cs4CL1 gene. Plant Science. 2018. ( IF 3.712 )
8. Liu X*, Liu TF*, Zhang YB*, Xin FJ, Mi SF, Wen BT, Gu TY, Wang FZ*, Sun LC*. Structural Insights into the Thermophilic Adaption Mechanism of Endo-1,4-β-Xylanase from Caldicellulosiruptor owensensis. JAFC. 2018. ( IF 3.412 )
9. Li SY, Jiang ZH, Sun LC, Liu X, Huang Y, Wang FZ*, Xin FJ*. Recombinant FIP-dsq2, a new Fungal Immunomodulatory Protein from Dichomitus squalens, interrupts Proliferation and Migration in Lung Cancer Cells. Journal of Biotechnology. 2017. ( IF 2.908).
10. Li SY, Jiang ZH, Xu WY, Xie YY, Zhao LM, Tang XM, Wang FZ*, Xin FJ*. FIP-sch2, a new fungal immunomodulatory protein from Stachybotrys chlorohalonata, suppresses proliferation and migration in lung cancer cells. Appl Microbiol Biol. 2016. ( IF 3.882).
11. Li SY, Zhao LM, Xu WY, Jiang ZH, Kang J, Wang, FZ*, Xin FJ*. Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. PLOS ONE, 2016, DOI: 10.1371/journal.pone.0168436. (IF 3.535).
12. Li J, Li SY, Wang FZ*, Xin FJ*.Structural and biochemical insights into the allosteric activation mechanism of AMP-activated proteinkinase. Chem Biol Drug Des. 2016，doi: 10.1111/cbdd.12897. (IF 2.422).
13. Xin FJ, Wang J. Zhao RQ, Wang ZX, Wu JW.(2013) Coordinated regulation of AMPK activity by multiple elements in the α-subunit. Cell Research. 2013. (IF: 15.393)
14. Xin FJ, Wu JW. (2013)Crystal structure of the p38α MAP kinase in complex with a docking peptide from TAB1. Science China Life Sciences. 2013. (IF: 3.085)
15. Chen L, Xin FJ, Wang J, Hu JC, Zhang YY, Wan S, Cao LS, Lu C, Li P, S.FrankYan, Dietbert Neumann, Uwe Schlattner, Xia B, Wang ZX, Wu JW. Conserved regulatory elements in AMPK. Nature. 2013. (IF: 41.458)

Awards/Achievements/...

Young talent plan winner of CAAS; Outstanding teacher for two consecutive years

Address: No 2, Yuanmingyuan West Rd., Beijing, P.R. China

Tel: +86-10-62815873

Fax: +86-10-62815873

Email: 2002hongzhi30@163.com, xinfengjiao@caas.cn