郭　维

博士招生专业：生物化学与分子生物学

研究方向：植物健康与食品安全

硕士招生专业：生物化学与分子生物学

研究方向：真菌毒素防控

一、个人简历

郭维，男，博士，研究员，博士生导师，中国农业科学院青年英才计划引进人才，国家农业科技创新工程真菌毒素防控创新团队科研骨干。长期从事植物健康与食品安全研究工作，在产毒真菌快速检测、真菌毒素合成调控机制、真菌毒素防控技术和微生物资源开发与利用等方面取得了创新性成果。主持或参与国家主体科研计划项目10余项；相关研究成果已发表学术论文27篇，其中SCI论文22篇，累计影响因子超过110，单篇最高11.70；申请国家发明专利3项，授权1项。 担任《Journal of Agricultural and Food Chemistry》、《Toxins》、《Scientific Reports》、《Plos One》和《International Journal of Food Microbiology》等SCI期刊的审稿人。

二、主要研究领域

1．  真菌毒素合成调控机制及防控技术开发

2．  真菌效应蛋白功能研究与产业化应用

3．  微生物资源开发与利用

三、主持的科研项目

1．  国家重点研发计划“食品中生物源危害物阻控技术及其安全性评价”课题“食品原料储藏霉菌及毒素阻控技术研究（2017YFC1600903）”，2018-2021

2．  国家自然科学基金面上项目 “大丽轮枝菌分泌的RNA沉默抑制子的鉴定与功能研究（31670143）”，2017-2020

3．  北京市自然科学基金面上项目“抑制寄主RNA沉默的效应蛋白FvRSS1在轮枝镰刀菌致病中的功能解析（6192023）”， 2019-2021

4．  国家重点基础研究发展计划（973计划）项目“主要粮油产品储藏过程中真菌毒素形成机理及防控基础”课题“储藏过程中真菌毒素为害机理（2013CB127803）”，2015-2017

5．  中国农业科学院基本科研业务费预算增量项目 “大丽轮枝菌中CBM效应子的鉴定与功能分析（2015ZL047）”, 2015-2016

四、科研产出

（一）代表性论文

1.      Guo W, Liew JY, Y. Adam Yuan. Structural insights into arms race between host and viruses along RNA silencing pathways in Arabidopsis thaliana (2014) Biological Reviews 89，337-355 (Cover feature)

2.      Xiuling Yang, Wei Guo, Fangfang Li, Garry Sunter, and Xueping Zhou* Geminivirus-Associated Betasatellites: Exploiting Chinks in the Antiviral Arsenal of Plants （2019）Trends in Plant Science 24, 6，519-529

3.      Nini Ma, Hafiz Abdul Haseeb, Fuguo Xing, Zengping Su, Liuying Shan, Wei Guo*. Fusarium avenaceum: A toxigenic pathogen causing ear rot on maize in Yunnan province, China (2019) Plant Disease

4.      Shan L, Hafiz Abdul Haseeb, Zhang J, Zhang D, Daniel Paul  Jeffers，Dai X*, Guo W*. A loop-mediated isothermal amplification (LAMP) assay for the rapid detection of toxigenic Fusarium temperatum in maize stalks and kernels (2019) International Journal of Food Microbiology 291， 72-78 

5.      Xi K, Shan L, Hafiz Abdul Haseeb, Guo W*, Dai X*. First report of Fusarium commune causing stalk rot on maize in Liaoning, China (2019) Plant Disease, 103:4, 773-773

6.      Shan L，Zhang J，Ma N，Dai X*, Guo W*. First report of maize stalk rot disease caused by Fusarium cerealis in Yunnan, China (2018). Plant Disease 2018 102:2, 444

7.      Shan L, Cui W, Zhang D, Zhang J, Ma N, Bao Y, Dai X*, Guo W*. First report of Fusarium brachygibbosum causing maize stalk rot in China (2017). Plant Disease 2017 101:5, 837

8.      Guo W, Jiang T, Zhang X, Li G, Zhou X*. Molecular variation of satellite DNA beta molecules associated with Malvastrum yellow vein virus and their role in pathogenicity (2008) Applied and Environmental Microbiology 74 (6), 1909

9.      Yang XL#, Guo W#, Ma XY, An Q, Zhou X*. Molecular characterization of Tomato leaf curl China virus infecting tomato in China and functional analyses of its associated betasatellite (2011) Applied and Environmental Microbiology 77, 3092

10.   Guo W#, Yang XL#, Xie Y, Cui X, Zhou X*. Tomato yellow leaf curl Thailand virus-[Y72] from Yunnan is a monopartite begomovirus associated with DNA beta. (2009) Virus Genes 38 (2), 328

11.   Yan X，Guo W，Adam Yuan*. Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease (2015) RNA biology 12(7):749

12.   Li L, Guo W, Xing Y, Zhang X, Li Z, Hu C, Li S, Li Y*, An Q*. The actinobacterium Microbacterium sp. 16SH accepts pBBR1-based pPROBE vectors, forms biofilms, invades roots, and fixes N2 associated with micropropagated sugarcane plants  (2011) Applied Microbiology and Biotechnology,

13.   Yang X, Wang Y, Guo W, Xie Y, Xie Q, Fan L, Zhou X*. Characterization of small interfering RNAs derived from the geminivirus/betasatellite complex using deep sequencing (2011) PLoS ONE 6 (2): e16928. doi:10.1371/journal.pone.0016928

14.   Lu Y, Yan F, Guo W, Zheng H, Lin L, Peng J, Michael J Adams, Chen J*. Garlic virus X 11-kDa protein granules move within the cytoplasm and traffic a host protein normally found in the nucleolus (2011) Molecular Plant Pathology 12 （7）666

15.   Wang H, Lei, Y, Yan, L, Cheng, K, Dai, X, Wan, L, Guo, W, Cheng, L, Liao, B*. Deep sequencing analysis of transcriptomes in Aspergillus flavus in response to resveratrol.(2015) BMC Microbiology 15, 182.

16.   Wan L, Li B, Pandey MK, Wu Y, Lei Y, Yan L, Dai X, Jiang H, Zhang J, Guo W, Varshney RK, Liao B* Transcriptome analysis of a new peanut seed coat mutant for the physiological regulatory mechanism involved in seed coat cracking and pigmentation.(2016) Frontiers in Plant Science, DOI:10.3389/fpls.2016.01491

17.   Wang H, Lei Y, Wan L, Yan L, Lv J, Dai X, Ren X, Guo W, Jiang H, Liao B* Comparative transcript profiling of resistant and susceptible peanut post-harvest seeds in response to aflatoxin production by Aspergillus flavus. (2016) BMC Plant Biology  16(1):54., DOI:10.1186/s12870-016-0738-z （IF=3.67）

18.   Wang H, Lei Y, Yan L, Wan L, Ren X, Chen S, Dai X, Guo W, Jiang H, Liao B* Functional genomic analysis of Aspergillus flavus interacting with resistant and susceptible peanut. (2016) Toxins 8(2):46., DOI:10.3390/toxins8020046

19.   Ding N, Xing F, Liu X, Selvaraj JN, Wang L, Zhao Y, Wang Y, Guo W, Dai X and Liu Y* Variation in fungal microbiome (mycobiome) and aflatoxin in stored in-shell peanuts at four different areas of China. (2015) Frontiers in Microbiology. 6:1055

（二）专利

1．  发明专利“一种大丽轮枝菌的单孢分离纯化方法”专利授权号：201410728350

2．  发明专利“环介导等温扩增法检测致病镰刀菌(Fusarium temperatum)的引物组合物和试剂盒及其用途” 专利申请号：201810313041.4

3．  发明专利“从感染病原菌的植物组织中分离病原菌分泌的质外体效应蛋白的方法”专利申请号：201910703471.1

五、主要社会兼职

1．  中国植物病理学会青年委员会委员

2．  中国植物病理学会会员

3．  中国菌物学会会员

4．  美国植物病理学会会员

5．  美国RNA协会会员

6．  北京市食品学会会员