郑金铠

博士招生专业：农产品加工利用

研究方向：果蔬营养健康与精深加工

硕士招生专业：食品科学

研究方向：果蔬功能成分的化学与生物学研究

一、个人简历

郑金铠，男，研究员，博士生导师。2010-2013年于美国马萨诸塞州立大学从事博士后和研究助理教授工作，2014年起就职于中国农业科学院农产品加工研究所，植物化学组分与组学研究创新团队首席科学家。2015年入选中国农业科学院“青年英才”；2021年获得“国家高层次人才特殊支持计划（万人计划）”国家青年拔尖人才荣誉称号和经费资助；2022年入选中国农业科学院“领军人才”。长期专注果蔬精深加工与营养健康研究，先后承担美国农业部、国家高层次人才特殊支持计划、国家自然科学基金、国家农业创新工程等国内外重大课题20余项；在国际权威期刊发表高水平SCI论文91篇，累计影响因子632，引用3100余次，H-因子31；其中，JCR一区论文76篇，10分以上论文24篇，权威综述8篇，ESI高被引5篇，期刊封面2篇；申请国家专利44项，已授权14项，主编书籍1部；开发新型高值化产品23件，并在雀巢、晨光、晟通、熙可等国际国内龙头企业示范推广并取得良好的经济社会效益。已培养博士、硕士研究生11名，其中获中国农业科学院优秀学位论文奖2人次、院级高水平论文奖3人次、国家奖学金4人次、国家留学奖学金6人次。

二、主要研究领域

1）深入挖掘植物（柑橘、葱姜蒜等）化学组分的材料特性和健康功能，通过多组学方法阐明其作用机理；

2）开展绿色高效制备、酶定向转化、原位高效分析、健康标记物快检、个性化体系设计等关键技术创新；

3）开发基于植物化学组分提取/精制产品、个性化设计/功能强化食品，及其他添加剂、日用品等。

三、承担课题

1. 国家高层次人才特殊支持计划（万人计划），140万，2021–2024。

2. 中国农业科学院“领军人才计划”，500万，2021–2026。

3. 中国农业科学院“青年英才计划”，300万，2015–2019。

4. 国家自然科学基金，“柑橘内源果胶/精油/黄酮组装体系体内消化规律与靶向递送”，2021–2024。

5. 国家自然科学基金，“柑橘多甲氧基黄酮PMFs的生物合成途径研究“，2021–2023。（指导）

6. 国家自然科学基金，“溶液环境调控柑橘果胶的聚集体结构和乳化机理研究”，2022–2024。（指导）

7. 国家自然科学基金，“基于柑橘内源组分提高多甲氧基黄酮生物利用度的作用机制研究”，2020–2022。（指导）

8. 国家自然科学基金，“柑橘多甲氧基黄酮硫酸酯代谢产物肠道水解机制研究”，2020–2022。（指导）

9. 国家自然科学基金，“适配体调控纳米磁性探针的菌群SERS检测及其传感机制研究”，2020–2022。（指导）

10. 国家自然科学基金，“柑橘多甲氧基黄酮类化学结构与生物活性的SERS同时识别研究”，2015–2017。

11. 国家自然科学基金，“基于食品基质效应增强亲脂活性成分生物利用度的研究”，2015–2016。

12. 国家农业创新工程“植物化学组分高值化利用”，2021–2025。

13. 农业部948项目，“果蔬加工副产物高值化利用技术”，2016–2018。

14 中国农业科学院所长基金，“柑橘精准营养机制研究”，2019–2021。

15. 世界龙头企业，“柑橘产品质量标准”， 2020–2022。

16. 国家龙头企业，“柑橘等果蔬保鲜技术”， 2020–2022。

17. 国家龙头企业，“柑橘副产物精深加工”，2019–2020。

18. 国家龙头企业，“NFC橙汁的技术开发”，2019–2021。

19. 省级龙头企业，“大蒜精深加工技术开发”，2018–2022。

20. 省级龙头企业，“黑蒜精深加工技术开发”，2019–2021。

四、近三年科研产出（2019.01—2022.6.30）

（一）25篇通讯作者发表的代表性论文

1) Jiefen Cui, Chengying Zhao, Liping Feng, Yanhui Han, Hengjun Du, Hang Xiao, Jinkai Zheng*. Pectins from fruits: Relationships among extraction methods, structural characteristics, and functional properties. Trends in Food Science & Technology, 2021, 110, 39–54. (影响因子16.002)

2) Jiefen Cui, Yunhe Lian, Chengying Zhao, Hengjun Du, Yanhui Han, Wei Gao, Hang Xiao, Jinkai Zheng*. Dietary fibers from fruits and vegetables and their health benefits via modulation of gut microbiota. Comprehensive Reviews in Food Science and Food Safety, 2019, 18, 1514–1532. (影响因子15.786)

3) Chang Lu, Shuaishuai Zhou, Fei Gao, Jianhan Lin, Juewen Liu, Jinkai Zheng*. DNA-mediated growth of noble metal nanomaterials for biosensing applications. Trends in Analytical Chemistry, 2022, 148, 116533. (影响因子 14.908)

4) Fei Gao, Shuaishuai Zhou, Chang Lu, Yuzhi Li, Jianhan Lin, Jinkai Zheng*. DNA-mediated Au@ Ag@ silica nanopopcorn fluorescent probe for in vivo near-infrared imaging of probiotic Lactobacillus Plantarum. Biosensors & Bioelectronics, 2022, 212, 114421. (影响因子12.545)

5) Chang Lu, Longhua Tang, Fei Gao, Yuzhi Li, Juewen Liu, Jinkai Zheng*. DNA-encoded bimetallic Au-Pt dumbbell nanozyme for high performance detection and eradication of Escherichia coli O157:H7. Biosensors & Bioelectronics, 2021, 187, 113327. (影响因子12.545)

6) Zhenyang Jiang, Shaojie Zhao, Minke Yang, Juan Li, Jinkai Zheng*. Structurally stable sustained-release microcapsules stabilized by self-assembly of pectin-chitosan-collagen in aqueous two-phase system. Food Hydrocolloids, 2022, 125, 107413. (影响因子11.504)

7) Zhenyang Jiang, Shaojie Zhao, Zhiying Fan, Chengying Zhao, Lin Zhang, Dan Liu, Yuming Bao, Jinkai Zheng*. A novel all-natural (collagen+pectin)/chitosan aqueous two-phase microcapsule with excellent anthocyanin loading capacity. Food Hydrocolloids, 2022, accepted. (影响因子11.504)

8) Qing An, Shaojie Zhao, Chengying Zhao, Rujun Wei, Lin Zhang, Yuming Bao, Lina Zhang, Jinkai Zheng*. Identification of the key emulsifying components from the byproducts of garlic oil distillation. Food Hydrocolloids, 2021, 122, 1070243. (影响因子11.504)

9) Jiefen Cui, Chengying Zhao, Shaojie Zhao, Guifang Tian, Feng Wang, Chunhong Li, Fengzhong Wang, Jinkai Zheng*. Alkali + cellulase extracted citrus pectins exhibit compact conformation and good fermentation properties. Food Hydrocolloids, 2020, 108, 106079. (影响因子11.504)  

10) Wenbo Ren, Shaojie Zhao, Yunhe Lian, Ying Yang, Guifang Tian, Chengying Zhao, Wei Gao, Jinkai Zheng*. (2020) Effects of hydrosoluble calcium ions and organic acids on citrus oil emulsions stabilized with citrus pectin. Food Hydrocolloids, 2020, 100, 105413. (影响因子11.504)

11) Xingmiao Lu, Chengying Zhao, Huan Shi, Yongcheng Liao, Fei Xu, Hang Xiao, Jinkai Zheng*. Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages. Critical Reviews in Food Science and Nutrition, 2022, doi: 10.1080/10408398.2022.1969891. (影响因子11.208)

12) Minke Yang, Juan Li, Chengying Zhao, Hang Xiao, Xiang Fang, Jinkai Zheng*. LC-Q-TOF-MS/MS detection of food flavonoids: Principle, methodology, and applications. Critical Reviews in Food Science and Nutrition, 2022, doi: 10.1080/10408398.2022.1993128. (影响因子11.208)

13) Abhisek Karn, Chengying Zhao, Feilong Yang, Jiefen Cui, Zili Gao, Minqi Wang, Fengzhong Wang, Hang Xiao, Jinkai Zheng*. In-vivo biotransformation of citrus functional components and their effects on health. Critical Reviews in Food Science and Nutrition, 2021, 61, 756–776. (影响因子11.208)

14) Chengying Zhao, Feng Wang, Yunhe Lian, Hang Xiao, Jinkai Zheng*. Biosynthesis of citrus flavonoids and their health effects. Critical Reviews in Food Science and Nutrition, 2020, 60, 566–583. (影响因子11.208）

15) Rujun Wei, Shaojie Zhao, Lin Zhang, Liping Feng, Chengying Zhao, Qing An, Yuming Bao, Lina Zhang, Jinkai Zheng*. Upper digestion fate of citrus pectin-stabilized emulsion: An interfacial behavior perspective. Carbohydrate Polymers, 2021, 264, 118040. (影响因子10.723)

16) Jiefen Cui, Wenbo Ren, Chengying Zhao, Wei Gao, Guifang Tian, Yuming Bao, Yunhe Lian, Jinkai Zheng*. The structure–property relationships of acid- and alkali-extracted grapefruit peel pectins. Carbohydrate Polymers, 2020, 229, 115524. (影响因子10.723)

17) Shaojie Zhao, Wenbo Ren, Wei Gao, Guifang Tian, Chengying Zhao, Jiefen Cui, Yunhe Lian, Jinkai Zheng*. Effect of mesoscopic structure of citrus pectin on its emulsifying properties: Compactness is more important than size. Journal of Colloid and Interface Science, 2020, 570, 80–88. (影响因子9.965)

18) Shuaishuai Zhou, Chang Lu, Yuzhi Li, Li Xue, Chengying Zhao, Guifang Tian, Yuming Bao, Longhua Tang, Jianhan Lin, Jinkai Zheng*. Gold nanobones enhanced ultrasensitive SERS aptasensor for detecting Escherichia coli O157:H7. ACS Sensors, 2020, 5, 588–596. (影响因子9.618)

19) Yuzhi Li, Chengying Zhao, Chang Lu, Shuaishuai Zhou, Guifang Tian, Lili He, Yuming Bao, Marie-Laure Fauconnier, Hang Xiao, Jinkai Zheng*. Simultaneous determination of 14 bioactive citrus flavonoids using thinlayer chromatography combined with surface enhanced Raman spectroscopy. Food Chemistry, 2021, 338, 128115. (影响因子9.231)

20) Huijuan Zhang, Jiefen Cui, Guifang Tian, Christina DiMarco-Crook, Wei Gao, Chengying Zhao, Genyuan Li, Yunhe Lian, Hang Xiao, Jinkai Zheng*. Efficiency of four different dietary preparation methods in extracting functional compounds from dried tangerine peel. Food Chemistry, 2019, 289, 340–350. (影响因子9.231)

21) Yuzhi Li, Chang Lu, Shuaishuai Zhou, Marie-Laure Fauconnier, Fei Gao, Bei Fan, Jianhan Lin, Fengzhong Wang, Jinkai Zheng**. Sensitive and simultaneous detection of different pathogens by surface-enhanced Raman scattering based on aptamer and Raman reporter co-mediated gold tags. Sensors and Actuators B: Chemical, 2020, 217, 128182. (影响因子9.221)

22) Huijuan Zhang, Guifang Tian, Chengying Zhao, Yanhui Han, Christina DiMarco-Crook, Chang Lu, Yuming Bao, Chengxiu Li, Hang Xiao, Jinkai Zheng*. Characterization of polymethoxyflavone demethylation during drying processes of citrus peels. Food & Function, 2019, 10, 5707–5717. (影响因子6.317)

23) Jiefen Cui, Feng Wang, Chengying Zhao, Shuaishuai Zhou, Jinkai Zheng*. Orange pectin with compact conformation effectively alleviates acute colitis in mice. Journal of Agricultural and Food Chemistry, 2022, 70, 1704−1714. (影响因子5.895)

24) Feng Wang, Chengying Zhao, Minke Yang, Lin Zhang, Rujun Wei, Kun Meng, Yuming Bao, Lina Zhang, Jinkai Zheng*. Four citrus flavanones exert atherosclerosis alleviation effects in ApoE^−/− mice via different metabolic and signaling pathways. Journal of Agricultural and Food Chemistry, 2021, 69, 5226−5237. (影响因子5.895)

25) Feng Wang, Chengying Zhao, Guifang Tian, Xue Wei, Zihan Ma, Jiefen Cui, Rujun Wei, Yuming Bao, Wei Kong, Jinkai Zheng*. Naringin alleviates atherosclerosis in ApoE^−/− mice by regulating cholesterol metabolism involved in gut microbiota remodeling. Journal of Agricultural and Food Chemistry, 2020, 68, 12651−12660. (影响因子5.895)

（二）10项第一发明人的代表性专利

1. 发明专利“一种具有肠道益生功能的柑橘果胶的制备方法”ZL202010041951.9.

2. 发明专利“一种基于双水相的纳米纤维素-果胶微囊的制备方法及应用” ZL201910062665.8.

3. 发明专利“一种含有多甲氧基黄酮的柑橘风味添加剂及其制备方法”ZL201811584224.6.

4. 发明专利“一种大蒜综合提取利用的方法”ZL201711218106.9.

5. 发明专利“一种基于DNA调控的金纳米棒检测重金属离子的方法”ZL201711450856.9.

6. 发明专利“一种陈皮的制备方法”ZL201611223001.8.

7. 发明专利“一种果蔬保鲜剂的制备方法与其应用”ZL201611010385.5.

8. 发明专利“一种实现食品成分化学结构与生物活性同时检测的技术”ZL201611209735.0.

9. 发明专利“一种检测多甲氧基黄酮类成分的方法”ZL201610726204.2.

10. 发明专利“一种粪便中脂溶性代谢成分的提取分离方法”ZL201610730674.6.

五、联系方式

联系电话：010-62819501

E-mail：jinkai8212@163.com；zhengjinkai@caas.cn.