邢福国

博士招生专业：生物化学与分子生物学

研究方向：微生物分子生物学与基因工程

硕士招生专业：生物化学与分子生物学

研究方向：微生物分子生物学与基因工程

 

一、个人简介
      邢福国，男，博士，研究员，博士生导师，中国农业科学院“青年英才”、国家真菌毒素防控科技创新联盟副秘书长。2001年获山东大学理学学士学位，2004年获山东大学理学硕士学位，2007年获中国科学院研究生院理学博士学位，2016年在美国农业部南方地区研究中心开展访学研究，2007年至今在中国农业科学院农产品加工研究所工作。长期从事农产品减损与真菌毒素防控研究工作，

在粮食无损检测和智能分选技术、粮食中真菌毒素精准绿色防控技术和污染粮食原料安全脱毒技术方面取得了一定成果。主持国家重点研发计划（基础研究类）课题2项、国家自然科学基金3项、公益性行业（农业）科研专项课题1项、973计划项目子课题1项、北京市自然科学基金2项；参与国家科技支撑计划、转基因重大专项、国家自然科学基金等国家级项目14项。获中国农业科学院杰出科技创新奖2项、中华农业科技奖二等奖1项、山东省科技进步奖2项、中国农业科学院“十二五”农产品质量安全亮点研究成果奖1项；以第一作者和通讯作者发表学术论文80余篇；授权国家发明专利40项。

二、主要研究领域

从事粮油减损与真菌毒素防控研究工作。主要研究领域：

1.粮油储运减损保质技术研发、集成与示范：阐明粮食产后收储过程中品质劣变、霉变及其调控的生化与分子机制；研发适宜产地和产后服务中心应用的智能、低耗、高效的中小型自适应烘储技术和装备；基于在线监测数据智能响应，以“高品质保粮”为目标，研发粮食仓储霉虫绿色精准防控技术和设施设备；鉴定仓储粮食品质劣变、霉变挥发性标志物， 研发仓储霉变在线监测预警技术。

2.真菌毒素合成调控机理与精准防控技术：研究水活度、温度、营养等环境因素对真菌毒素合成的影响，采用多组学技术解析环境因素调控真菌毒素生物合成的基因网络；在食品贮藏、加工过程中，开展真菌毒素的阻断、抑制技术研究及产品研发，采用多组学技术揭示抑制剂阻断、抑制真菌毒素生物合成的生化机制与分子机理。

3.农产品质量安全检测技术：采用高光谱成像技术，解析霉变及真菌毒素污染粮油产品的光谱变异规律，研发霉变及真菌毒素污染粮油产品的分选去除技术及设备；研发食品真菌毒素、致病菌等生物危害物的快速检测技术与产品。

三、承担课题
1.主持国家重点研发计划课题（基础研究类）“生鲜农产品病原性腐败机制与调控（2022YFD2100104）”，2022-2027；

2.主持国家重点研发计划课题（基础研究类）“生鲜食用农产品水活度和微生物调控品质劣变机理（2016YFD0400105）”，2016-2020；

3.主持国家自然科学基金面上项目“Fus3-MAPK信号通路调控黄曲霉毒素合成的分子机制（31972179）”，2020-2023；

4.主持国家自然科学基金面上项目“肉桂醛抑制黄曲霉毒素生物合成的分子调控机理（31571938）”，2016-2019；

5.主持国家自然基金青年基金“Bt杀虫蛋白和伏马菌素B1的联合肠道免疫毒性（31000776）”，2011-2013；

6.主持北京市自然科学基金面上项目“玉米淀粉加工中伏马菌素B1的迁移、降解机理（6132026）”，2013-2015；

7.主持中国农业科学院基本科研业务费专项“酚醛类植物提取物抑制黄曲霉毒素生物合成的分子调控机理研究（S2016JC02）”，2016-2018；

8.主持企业合作技术开发项目（北京美正生物科技有限公司）“食品安全检测标准物质的研发和制备”，2017-2022；

9.主持公益性行业（农业）科研专项“粮油真菌毒素控制技术研究”，2012-2016；

10.主持中国农业科学院“科研英才培育工程”院级入选项目“生物抑制剂抑制黄曲霉毒素生物合成的分子调控机理研究”，2017-2023；

11.参加转基因重大专项子课题“转基因生物的食用和饲用安全评价技术”，2016-2020；

12.参加国家科技支撑计划子课题“食用农产品加工适宜性评价及风险监控技术研究与示范”，2012-2015。

四、近三年科研产出

参编专著2部，发表研究论文40篇，获得授权专利5项。

（一）代表著作
1.参编《农产品加工适宜性评价与风险监控》，2022年8月，编委，北京：科学出版社。

2.参编《2019年农产品加工业科技创新发展报告》，2020年9月，编委，北京：中国农业科学技术出版社。

（二）代表科技论文

1. Israt Jahan1, Bowen Tai1, Junning Ma, Sarfaraz Hussain, Haolan Du, Ling Guo, Gang Wang, Tosin Victor Adegoke, Longxue Ma, and Fuguo Xing*. Identification of a novel Bacillus velezensis IS-6 Nudix hydrolase Nh-9 Involved in ochratoxin A detoxification by transcriptomic profiling and functional verification. Journal of Agricultural and Food Chemistry, 2023. https://doi.org/10.1021/acs.jafc.3c01910

2. Junning Ma1, Yue Guan1, Fuguo Xing*, Evgeni Eltzov, Yan Wang, Xu Li, Bowen Tai. Accurate and non-destructive monitoring of mold contamination in foodstuffs based on whole-cell biosensor array coupling with machine-learning prediction models. Journal of Hazardous Materials, 2023, 449: 131030.

3. Junning Ma1, Yue Guan1, Fuguo Xing*, Yan Wang, Xu Li, Qiang Yu, Xiaohua Yu. Smartphone-based chemiluminescence detection of aflatoxin B1 via labelled and label-free dual sensing systems. Food Chemistry, 2023, 413: 135654.

4. Bolei Yang1, XiaohuaYu1, Jihao Shan1, Xiaoyu Tian, Tosin Victor Adegokea, Shuo Yang, Gang Wang, Bowen Tai, Junning Ma, QiangYu, FuguoXing*. Migration of hazardous substances during peanut oil squeezing for their dietary assessment. Food Control, 2023, 150: 109760.

5. Yue Guan1, Junning Ma1, Jing Neng, Bolei Yang, Yan Wang*, Fuguo Xing*. A novel and label-free chemiluminescence detection of zearalenone based on a truncated aptamer conjugated with a G-quadruplex DNAzyme. Biosensors, 2023, 13(1): 118.

6. Chenxi Zhang1, Lin Pan1, Junning Ma1, Qiang Yu, Xiaohua Yu, Sarfaraz Hussain, Xu Li, Yujie Li, Yue Guan, Yifei Li, Fuguo Xing*. Microencapsulation enhances the antifungal activity of cinnamaldehyde during the period of peanut storage. LWT, 2023, 180: 114657.

7. Jing Jin, Chen Zhang, Xiaoxu Ren, Bowen Tai, Fuguo Xing*. Metagenome analysis identifies microbial shifts upon deoxynivalenol exposure and post-exposure recovery in the mouse gut. Toxins, 2023, 15: 243.

8. Si Peidong, Gang Wang, Wenqing Wu, Sarfaraz Hussain, Ling Guo, Wei Wu, Qingli Yang, Fuguo Xing*. SakA regulates morphological development, ochratoxin A biosynthesis and pathogenicity of Aspergillus westerdijkiae and the response to different environmental stresses. Toxins, 2023, 15(4): 292.

9. Gang Wang1, Erfeng Li1, Antonia Gallo, Giancarlo Perroned, Elisabeth Vargae, Junning Ma, Bolei Yang, Bowen Tai, Fuguo Xing*. Impact of environmental factors on ochratoxin A: From natural occurrence to control strategy. Environmental Pollution, 2023, 317: 120767.

10. Francis Nosakhare Imade, Muhammad Humza, Oyeyemi Adigun Dada, Sana Ullah, Israt Jahan, Daniel Eseigbe, Hairong Geng, Yongquan Zheng, Fuguo Xing*, Yang Liu*. Isolation and characterization of novel soil bacterium, Klebsiella pneumoniae strain GS7-1 for the degradation of zearalenone in major cereals. Food Control, 2023, 143: 109287.

11. Tosin Adegoke, Bolei Yang, Fuguo Xing*, Xiaoyu Tian, Gang Wang, Bowen Tai, Peidong Si, Sarfaraz Hussain, Israt Jahan. Microbial enzymes involved in the biotransformation of major mycotoxins. Journal of Agricultural and Food Chemistry, 2023, 69: 15384-15392.

12. Lu Sun1, Runyan Li1, Bowen Tai1, Sarfaraz Hussain, Gang Wang, Xiumin Liu*, Fuguo Xing*. Current status of major mycotoxins contamination in food and feed in Asia─A Review. ACS Food Science & Technology, 2023, 3, 231-244.

13. Ahmad T, Xing F, Nie C, Cao C, Xiao Y, Yu X, Moosa A and Liu Y. Biocontrol potential of lipopeptides produced by the novel Bacillus subtilis strain Y17B against postharvest Alternaria fruit rot of cherry. Front. Microbiol. 14:1150217.

14. Boris Veltman1, Junning Ma1, Dorin Harpaz, Fuguo Xing, Evgeni Eltzov*. Genetically engineered bacterial strains constructed as a whole-cell biosensor for specific volatiles identification of infected potato tubers with a soft rot disease. Sensors and Actuators: B. Chemical, 2023, 387: 133788.

15. Longxue Ma1, Xu Li1, Fuguo Xing*, Junning Ma, Xiaoyun Ma, Yiran Jiang. Fus3, as a critical kinase in MAPK cascade, regulates aflatoxin biosynthesis by controlling the substrate supply in Aspergillus flavus, rather than the cluster genes modulation. Microbiology Spectrum, 2022, 10(1): e01269-21.

16. Bolei Yang1, Jihao Shan1, Fuguo Xing*, Xiaodong Dai, Gang Wang, Junning Ma, Tosin Victor Adegoke, Xinyou Zhang, Qiang Yu, Xiaohua Yu. Distribution, accumulation, migration and risk assessment of trace elements in peanut-soil system. Environmental Pollution, 2022, 304: 119193.

17. Gang Wang1, Yujie Li1, Bolei Yang, Erfeng Li, Wenqing Wu, Peidong Si, Fuguo Xing*. AwAreA regulates morphological development, ochratoxin A production and fungal pathogenicity of food spoilage fungus Aspergillus westerdijkiae revealed by an efficient gene targeting system. Frontiers in Microbiology, 2022, 13: 857726.

18. Bolei Yang1, Li Li1, Hairong Geng1, Xiujuan Zhang, Sheng Gao, Gang Wang, Chenxi Zhang, Yueju Zhao, Yuming Bao, Fuguo Xing*, Yang Liu *. Detoxification of aflatoxin B1 by H2SO3 during maize wet processing, and toxicity assessment of the transformation product of aflatoxin B1. Food Control, 2022, 131: 108444.  

19. Fangfang Li1, Jing Jin1, Ivonne M.C.M. Rietjens, Fuguo Xing*. Interindividual differences in in vitro human intestinal microbial conversion of 3-Acetyl-DON and 15-Acetyl-DON. Toxins, 2022, 14: 199.

20. Xiaoyun Ma1, Yiran Jiang1, Longxue Ma, Shujuan Luo, Haolan Du, Xu Li *, Fuguo Xing *. Corepressors SsnF and RcoA regulate development and aflatoxins B1 biosynthesis in Aspergillus flavus NRRL 3357. Toxins, 2022, 14: 174.

21. Sarfaraz Hussain1, Bowen Tai1, Athar Hussain, Israt Jahan, Bolei Yang, Gang Wang, Fuguo Xing*. Genome-wide identification and expression analysis of the basic leucine zipper (bZIP) transcription factor gene family in Fusarium graminearum. Genes, 2022, 13: 607.

22. Jiahui Xu, Zhaoqing Sun, Rui Zhang, Ruixue Li, Zhecong Yu, Qianlong Zhang, Yanan Ma, Fuguo Xing*, Liqiang Zheng*. Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study. Frontiers in Aging Neuroscience, 2022, 14: 924984.

23. HaoLan Du, Tanvir Ahmad, Mingjun He, Anam Moosa, Yongquan Zheng, Nie Chengrong, Fuguo Xing*, Yang Liu*. First record of leaf spot of Ficus religiosa caused by Alternaria alternata in Pakistan. Plant Disease, 2022.

24. Peng Chang1, Bowen Tai1, Mumin Zheng, Qingli Yang*, Fuguo Xing*. Inhibition of Aspergillus flavus growth and aflatoxin B1 production by natamycin. World Mycotoxin Journal, 2022, 15(3): 269-283.

25. Lin Chen1, Erfeng Li1, Wenqing Wu1, Gang Wang*, Jiaqian Zhang, Xu Guo, Fuguo Xing. The secondary metabolites and biosynthetic diversity from Aspergillus ochraceus. Frontiers in Chemistry, 2022, 10: 938626.

26. Liqiang Zheng*, Yanxia Xie, Zhaoqing Sun, Rui Zhang, Yanan Ma, Jiahui Xu, Jia Zheng, Qianyi Xu, Zhao Li, Xiaofan Guo, Guozhe Sun, Fuguo Xing, Yingxian Sun‡ Deliang Wen. Serum spermidine in relation to risk of stroke: A multilevel study. Frontiers in Nutrition, 2022, 9: 843616.

27. Jing Jin, Albertus Spenkelink, Karsten Beekmann, Marta Baccaro, Fuguo Xing*, Ivonne M.C.M. Rietjens. Species differences in in vitro and estimated in vivo kinetics for intestinal microbiota mediated metabolism of acetyl-deoxynivalenols. Molecular Nutrition & Food Research, 2021, 65, 2001085. DOI: 10.1002/mnfr.202001085. Published online: March 11, 2021

28. Xu Li1, Yaoyao Ren1, Jin Jing, Yiran Jiang, Qingli Yang, Shujuan Luo, Fuguo Xing*. The inhibitory mechanism of methyl jasmonate on Aspergillus flavus growth and aflatoxin biosynthesis and two novel transcription factors are involved in this action. Food Research International, 2021, 140: 110051.

29. Bolei Yang1, Li Li1, Hairong Geng1, Chenxi Zhang, Gang Wang, Shuo Yang, Sheng Gao, Yueju Zhao, Fuguo Xing*. Inhibitory effect of allyl and benzyl isothiocyanates on ochratoxin A producing fungi in grape and maize. Food Microbiology, 2021, 100: 103865.

30. Jing Jin, Mouhamed Fall, Qijun Liu, Ivonne Rietijens, Fuguo Xing*. Comparative microbial conversion of deoxynivalenol and acetylated deoxynivalenol in different parts of chicken intestine as detected in vitro and translated to the in vivo situation. Journal of Agricultural and Food Chemistry, 2021, 69: 15384-15392.

31. Li Li1, Bolei Yang1, Muhammad Humza, Hairong Geng, Gang Wang, Chenxi Zhang, Sheng Gao, Fuguo Xing*, Yang Liu*. A novel strain Lactobacillus brevis 8-2B inhibiting Aspergillus carbonarius growth and ochratoxin A production. LWT-Food Science and Technology, 2021, 136: 110308.

32. Jing Jin, Karsten Beekmann, Einar Ringø, Ivonne M.C.M. Rietjens, Fuguo Xing*. Interaction between food-borne mycotoxins and gut microbiota: a review. Food Control, 2021, 126: 107998.

33. Longxue Ma1, Xu Li1, Xiaoyun Ma, Qiang Yu, Xiaohua Yu, Yang Liu, Chengrong Nie, Yinglong Zhang*, Fuguo Xing*. The regulatory mechanism of water activities on aflatoxins biosynthesis and conidia development, and transcription factor AtfB is involved in this regulation. Toxins, 2021, 13: 431.

34. Qijun Liu, Xu Li, Riqin Wu, Xinglong Xiao*, Fuguo Xing*. Development of an on-spot and rapid recombinase polymerase amplification assay for Aspergillus flavus detection in grain. Food Control, 2021, 125: 107957.

35. Haiyong Zhang1, Gang Wang1, Qingli Yang, Xu Yang, Yongquan Zheng, Yang Liu*, Fuguo Xing*. Effects of light on the ochratoxigenic fungi Aspergillus ochraceus and A. carbonarius. Toxins, 2021, 13: 251.

36. Shujuan Luo, Haolan Du, Haftom Kebede, Yang Liu*, Fuguo Xing*. Contamination status of major mycotoxins in agricultural product and food stuff in Europe. Food Control, 2021, 127: 108120.

37. Muhammad Humza1, Li Li1, Gang Wang, Shujian Huang, Mingjun He, Chengrong Nie, Yongquan Zheng, Babar Iqbal, Fuguo Xing*, Yang Liu*. Evaluation of growth media and in vitro conditions for the assessment of Aspergillus flavus growth and aflatoxin B1 in grapes. Pakistan Journal of Agricultural Sciences, 2021, 58(2): 447-460.

38. Jiadi Sun, Miao Li, Fuguo Xing, Haiming Wang, Yinzhi Zhang, XiulanSun*. Novel dual immunochromatographic test strip based on double antibodies and biotin-streptavidin system for simultaneous sensitive detection of aflatoxin M1 and ochratoxin A in milk. Food Chemistry, 2021, 131682.

39. Yan Wang, Wei Lin, Hao Yan*, Jing Neng, Yong Zheng, Kai Yang*, Fuguo Xing, Peilong Sun. iTRAQ proteome analysis of the antifungal mechanism of citral on mycelial growth and OTA production in Aspergillus ochraceus. Journal of the Science of Food and Agriculture, 2021, DOI: 10.1002/jsfa.11140.

40. Francis Imade, Edgar Mugizi Ankwasa, Hairong Geng, Sana Ullaha, Tanvir Ahmad, Gang Wang, Chenxi Zhang, Oyeyemi Dada, Fuguo Xing, Yongquan Zheng, Yang Liu*. Updates on food and feed mycotoxin contamination and safety in Africa with special reference to Nigeria. Mycology, 2021, 12(4): 245-260.

（三）专利

1.发明专利“复合植物提取物及其在粮食储藏防霉中的应用”，专利号ZL201711230734.9

2.发明专利“苯丙环戊酮衍生物及其制备方法与应用”，专利号ZL201910620190.X

3.发明专利“抑制粮食中黄曲霉生长及毒素产生的方法”，专利号ZL201911031450.6

4.发明专利“缺陷短波单胞菌及其应用和降解真菌毒素的方法”，专利号ZL202011048286.2

5.发明专利“复合菌剂及其用途”，专利号ZL202011403339.8

五、主要社会兼职

兼任国家真菌毒素防控科技创新联盟副秘书长、Frontier in Microbiology编委、Frontier in Nutrition编委、Toxins编委

六、联系方式

联系电话：010-62819472、010-62811868、15801607126

传 真：010-62811868

E-mail：xingfuguo@caas.cn